Enhanced Drug Delivery:Using HME Technology for Better Formulations & Solubility

Duration: 1 hour

Hot melt extrusion (HME) is a highly promising technology. It has gained recognition in the pharmaceutical industry for its ability to address several challenges. HME can effectively enhance the solubility of poorly soluble drugs, create sustained-release formulations, and mask the unpleasant taste of drugs. In addition, HME offers a continuous and scalable process, making it an attractive alternative for the manufacturing of oral dosage forms. Despite its potential, several misconceptions surrounding HME hinder its full utilization.

This upcoming webinar will be designed to offer a comprehensive insight into the development of oral dosage forms using HME. The session will be led by industry experts who will discuss the principles and mechanisms of HME and shed light on its advantages over traditional manufacturing techniques. Experts will discuss how extruder configuration affects amorphous solid dispersion, process parameters, and final product quality. They will also cover the topic of scalability. Additionally, the webinar will present a systematic, phase-appropriate, and fast-track approach to enhance the bioavailability of poorly soluble drugs. Attendees will also get to explore several case studies showcasing successful applications of HME in oral dosage form development.

Key learning objectives

  • Explore the key principles and applications of hot melt extrusion as an amorphous solid dispersion technology.
  • Learn recent innovations in equipment engineering for hot-melt extrusion as applied to pharmaceutical product manufacturing.
  • Discuss the systematic, phase appropriate and fast-track approach to developing bioavailability enhanced oral dosage forms.
  • Explore case studies that effectively debunk the commonly held misconceptions surrounding the limitations of HME.


Charlie Martin
Leistritz Extrusion

Hibre Terefe Ph.D.,
Director Research and Development


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