Moisture content is an important variable that must be monitored for and controlled during the production of plastic medical device parts. ASTM standard D6869 is the benchmark for measuring the moisture content of plastic resin, and stipulates the use of Karl Fischer titration as the applicable standard method. Herein, we show that the Sartorius Mark 3 High Performance Moisture Analyzer correlates well with Karl Fischer titration standards for a number of plastic resins commonly used in medical device manufacture.