ON DEMAND WEBINAR
Duration: 30 Minutes​

Current DNA synthesis technology relies on chemistry that damages DNA during its synthesis, leading to limited oligonucleotide length, unreliability and failure to deliver complex DNA. In this webinar, we discuss the new Ansa DNA Fragments and Ansa Clonal DNA products, that offer synthesis of long oligonucleotides using our unique linker nucleotide-polymerase conjugate technology. These long oligos sidestep the need for oligo assembly, enabling reliable delivery of complex clonal and fragment DNA including long homopolymers, short tandem repeats (STRs), block repeats (e.g. promoters) and inverted repeats (ITRs).

We are joined by one of our customers in the Innovative Genomics Institute at UC Berkeley. They are pioneering Precision Microbiome Editing to tackle challenges in personalized medicine, sustainability, agriculture, and climate. Their approach involves analyzing metagenomic data to uncover the mechanisms nature has evolved for transferring, manipulating, and restricting genetic material within microbial communities. This knowledge enables them to discover new tools – such as novel plasmids, viruses, and gene editors – that can significantly enhance microbial engineering. However, many of these elements are embedded in highly repetitive and complex DNA sequences, making them challenging to synthesize and study in the lab. To overcome this, they increasingly depend on Ansa’s advanced DNA synthesis technology, which grants them access to these potentially transformative genetic tools.

Key Takeaways

• Learn about Ansa's unique enzymatic approach to DNA synthesis.
• By synthesizing complex DNA fragments like multiplexed CRISPR arrays, Transposons, and Retrons, our customer is working to unlock creative and enabling microbial synthetic biology tools.
• Developing delivery methods for microbial genome editors, such as bacteriophage and plasmids, similarly requires access to complex DNA synthesis. Hear how they have worked with Ansa to achieve this.

SPEAKERS

Eric Estrin, PhD
Head of Biochemistry
Ansa Biotechnologies

Jaymin Patel, PhD
Postdoctoral Researcher in the Cress and Doudna Labs
Innovative Genomics Institute, UC Berkeley